By J. X. Thomas Jr. Ph.D., M. W. Gerdisch (auth.), Gerd Heusch, John Ross Jr. (eds.)
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Additional resources for Adrenergic Mechanisms in Myocardial Ischemia
Indeed, IX-receptor blockade by phentolamine and prazosin significantly reduced ventricular arrhythmias during coronary occlusion, especially during reperfusion in various species [17,124,128,147). So far, it has remained speculative which electrophysiological actions of noradrenaline contribute to the pathogenesis of ventricular arrhythmias during myocardial ischemia [15,18,59,77]. On the cellular level, catecholamines interfere via stimulation of p-receptors with various components of the action potential, such as amplitude, duration, refractoriness, and conduction velocity depending on the type of cardiac tissue.
Graefe KH, Zeitner CJ, Fuchs G, Keller B (1984) Role played by sodium in the membrane transport of 3H-noradrenaline across the axonal membrane of noradrenergic neurones. In: Fleming WW (Ed) Neuronal and Extraneuronal Events in Autonomic Pharmacology. Raven Press, New York, pp 51-62 47. Griffiths J, Leung F (1971) The sequential estimation of plasma catecholamines and whole blood histamine in myocardial infarction. Am Heart J 82: 171-179 48. Haass M, Cheng B, Richardt G, Lang RE, Schomig A (1989) Characterization and presynaptic modulation of stimulation-evoked exocytotic co-release of noradrenaline and neuropeptide Y in guinea pig heart.
Am J Physiol 247: E21-E28 37. Euler von US, Lishajko F (1963) Effect of adenine nucleotides on catecholamine release and uptake in isolated adrenergic nerve granules. Acta Physiol Scand 59: 454-461 38. Fearon RE (1967) Propranolol in the prevention of ventricular fibrillation due to experimental coronary artery occlusion. Am J Cardiol 20: 222-228 39. Fiolet JWT, Baartscheer A, Schumacher CA, Coronel R, ter Welle HF (1984) The change of the free energy of ATP hydrolysis during global ischemia and anoxia in the rat heart.
Adrenergic Mechanisms in Myocardial Ischemia by J. X. Thomas Jr. Ph.D., M. W. Gerdisch (auth.), Gerd Heusch, John Ross Jr. (eds.)